Paclitaxel is really a well-known anticancer agent having a unique mechanism of action. It is regarded as probably the most effective natural anticancer drugs available. This research summarizes the current advances within our knowledge of the sources, the anticancer mechanism, and also the biosynthetic path of paclitaxel. Using the growth of biotechnology, enhancements in endophytic yeast strains, and using recombination techniques and microbial fermentation engineering, the yield of extracted paclitaxel has elevated considerably. Lately, paclitaxel has been discovered to experience a sizable role in tumor immunity, and contains an excellent possibility of use within many cancer treatments.